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Of the six studies that measured co-factors of the -glutamyl cycle or trans-sulphuration pathway, five studies showed elevated levels of vitamin B6 in children with autistic disorder or autism spectrum disorders compared to controls [73, 76, 87, 92, 93], one showed a decrease in erythrocyte selenium in children with autistic disorder [78] and another showed no change in whole blood selenium in children with an autism spectrum disorder compared to controls [87]

PMID: 41093057 Cell Rep Med 2026 Jun 18:102875

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10.1016/S0006-3223(99)00203-6 65 SudheimerK

Metabolites in green were present at lower levels in the astrocytes of the 5xFAD group compared with the control group