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The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases

Mol Nutr Food Res 2015;59:1364-1372

The company had no role in designing the study, running the surveys, analyzing and interpreting the data, or drafting the manuscript

These symptoms are usually mild to moderate and tend to lessen over time

How long it takes you to get to sleep, how often you wake, how easy you find it to drift off again, how long your actual sleep is, and how refreshed you feel in the morning