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Notably, the regulatory subunit, MAT2B, was unaffected by these metabolic perturbations (Fig
Furdui, Cristina M

Martin-Bastida A, Lao-Kaim NP, Loane C et al (2017a) Motor associations of iron accumulation in deep grey matter nuclei in Parkinsons disease: a cross-sectional study of iron-related magnetic resonance imaging susceptibility

Conversely, the downregulation of NRF2 by FTH (ferritin heavy chain), NQO1 (NAD(P)H quinone oxidoreductase-1), and HO-1 (heme oxygenase1) amplified the sensitivity to ferroptosis in HCC [92]
Diabetologia 52 , 18811888 (2009)

For these reasons nicotinic acid therapy is not recommended for diabetics or persons who suffer from gout