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Peak synergy occurred when 2 nM vincristine was combined with 7.8 nM DPI, with an associated ZIP score of 13.6 ( Figure 5B )
The nasal spray route uses the olfactory pathway to bypass the blood-brain barrier and delivers the peptide directly to the central nervous system
This efficiency is particularly important in neurons, where rapid local protein synthesis can be crucial for synaptic plasticity and the overall maintenance of neural networks [50,51]
For non-reversible treatments, we under-treat first by design and add more at follow-up
License Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Content URL Doctor's Note This is part of my extended look at B12
Braz J Microbiol
