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SVR rates of 99% have been observed for HCV GT2 with sofosbuvir/velpatasvir or glecaprevir/pibrentasvir treatment in patients that previously failed therapy with pegIFN and RBV or a combined sofosbuvir and RBV treatment (Feld et al., The efficient replication by the JFH-1 replicon makes it among the most extensively used replicon systems for identifying pangenotypic HCV inhibitors

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Gastroenterology 132 , 13591374 (2007)

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Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology