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This mutation (Val6Glu) causes the Hb tetramer to have different properties

To this end, the corresponding stoichiometric coefficients of each compound consumed for biomass or virion production were multiplied by the molecular weight of the corresponding compound

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This section systematically details the hierarchical, multimodal therapeutic frameworks for each subtype, with clinical trials summarized in Table 2

However, its successful application will require further elucidation of TREM biology in humans, regarding the cell-type specificity of TREM expression (e.g., in astrocytes, oligodendrocytes, and neurons), species differences between humans and mice, immature metabolic and mitochondrial features of in vitro culture (e.g., BV and iPSC-derived cells), early-onset or late-onset, and the temporal dynamics of disease progression with senescence

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