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In one trinitrobenzene sulphonic acid (TNBS)-induced colitis study, pretreatment of rats with RSV reduced histologic inflammation and MDA levels but increased GPx activity compared to markers in the TNBS and vehicle groups (91) ( Supplementary Table 1 )

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Although emerging strategies such as C5aR antagonists or CR2-CD59 fusion proteins have demonstrated in animal models the ability to achieve tissue-specific inhibition by targeting the C5a-C5aR axis, thereby reducing inflammatory damage while preserving physiological complement functions (143), their clinical translation is still hampered by difficulties in target validation, substantial inter-individual variability in response and a lack of long-term safety data

On the mechanisms of the radiation-induced degradation of cellulosic substances

The study revealed that gender, BMD screening, and anti-osteoporotic medication were not associated with the quality of life