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doi: 10.1038/nrd781

This analysis excluded trials in those with end-stage renal disease, who are at high risk of cardiovascular events and mortality

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doi: 10.3389/fcvm.2018.00107

Skin Alterations If you notice that the skin around where your muscle spasms occur has any changes, such as a rash, redness, edema, or discoloration, its essential to consult a healthcare professional