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However, co-IP experiments with SPOC domains or full-length proteins show that DIDO may have a similar or even stronger affinity for Pol II in cells, which may be due to higher expression levels and stability compared to PHF3 (Fig

10.3390/ani10122198 Animals
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Transitions from desensitized to resting/closed state require substantial conformational changes in LBD and the LBD-TM linkers In the gating cycle, post-desensitization, receptor needs to recover to a resting state, where the LBDs couple as 2-dimers for the next cycle of activation

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[92] Despite receiving mixed reviews from critics, the film earned Affleck Screen Actors Guild Award and Golden Globe Award nominations for Best Supporting Actor