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Description
Hypothalamic bile acid-TGR5 signaling protects from obesity
It primarily consists of parallelly arranged collagenous fibers
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The lead compound, 83 , proved to be a mixedtype nonpurine XO inhibitor, and through in vitro inhibition of bovine XO, the compound showed IC 50 values of 0.121 M, which was approximately 63 times more potent than allopurinol, the standard drug used as a control (Figure 26)
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