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Immune cells, such as macrophages and neutrophils, can also generate ROS due to their oxygen-dependent mechanisms to fight against invading microorganisms based on NOX2 isoform ( ROS are produced in mitochondria during aerobic metabolism (Rodriguez and Redman, 2005)
Nat Rev Dis Primers 2017;3:17018
Mar;52(3):74959
So far, I have never failed a case
In addition to IFN-, other players could be of relevance in the dysregulation of TJs
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