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However, the seleno-protein GPx2 plays an important role in the progression of malignant tumors [312]

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As indicated in the Glycolysis and the Regulation of Blood Glucose page, as well as in the Metabolic Alterations Associated with Cancer page, and in the section above on SDH-deficient tumors, the common changes in metabolic profiles in cancer cells is, in part, the result of the activation of the hypoxia induced factor 1 (HIF-1) transcriptional program

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