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In laboratory research models, GSH exerts its antioxidant activity through direct scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as through serving as an essential cofactor for glutathione peroxidase (GPx) enzymes, which catalyse the reduction of hydrogen peroxide and lipid hydroperoxides to non-toxic products
Although some FAO inhibitors, such as etomoxir, have shown great potential in preclinical experiments, their clinical transformation has been hampered by high toxicity, dose tolerance and poor specificity [206]

Redox Signal 20, 11261167

doi: 10.1186/s12987-020-00230-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 45.Shi FD, Yong VW
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et al., (2021), H2AFJ increase in AD induced-neurons (iNs
