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Significant changes in TCA intermediates fumarate and succinate, and in the secondary TCA metabolites succinyl-carnitine and methyl succinyl-carnitine were observed, arguing that the potential anti-inflammatory properties of these metabolites are mediated by metabolic rewiring

In AD peripheral lymphocytes, GSH levels are decreased and GSSG levels are increased, consistent with increased oxidative stress [27]

A list of principal investigators, affiliated study sites, and information regarding the overseeing IRB is provided in Supplementary Table 1

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Progesterone dampens immune responses in in vitro activated CD4+ T cells and affects genes associated with autoimmune diseases that improve during pregnancy