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Considering that the Hedgehog pathway is implicated in the initiation and maintenance of PAAD [82] and NNMT is a potential downstream target gene of Hedgehog, the elevation of NNMT level in PAAD may be a result of the continuously activated Hedgehog signaling pathway

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10.1021/bi201509f [DOI] [PubMed] [Google Scholar] 27.Gul R, Park DR, Shawl AI, Im SY, Nam TS, Lee SH, et al

Furthermore, there was a reduction in the use of concomitant analgesic medication in 76% of study subjects

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