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The pancreatic secretion of intrinsic factor is reduced or absent, secondary dysbiosis of the intestine is common, and the mucosa may be compromised by the presence of excessive bacterial numbers and toxic metabolites

doi: 10.1038/mtna.2015.28, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 72.Sinenko SA, Ponomartsev SV, Tomilin AN

10.1016/j.yexcr.2017.11.004 154 WangW.CassidyJ

Researchers propose that MOTS-c acts as an endocrine-like factor a mitochondrial hormone that helps coordinate metabolism and stress responses across the body, thereby affecting the aging process

doi: 10.1016/j.intimp.2016.10.008