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This study highlights the importance of rare genetic variants in understanding the genetic architecture of alcohol metabolism, expanding the scope of research in potential pharmacological targets beyond common variants in ADH and ALDH

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Sperm cells are particularly susceptible to oxidative and reductive imbalances because of their structural features, which include a high membrane concentration of polyunsaturated fatty acids, weak antioxidant defenses, and rapid metabolic activity [4]

Community observations should inform but not replace careful individual risk assessment

Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: gender-related difference in metabolism of Schisandra lignans in rats