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53 published the first clinical study addressing the immunosuppressive effects of MSCs in the treatment of isolated GVHD, significantly advancing the clinical exploration of the use of MSCs for a variety of immune disorders
10.3892/ol.2019.9973 172 WangD.WangX.SongY.SiM.SunY.LiuX.et al (2022)
Doses Per Vial Vial duration varies by dose escalation phase: 3mg vial: At 0.25mg/week = 12 weeks At 0.5mg/week = 6 weeks At 1mg/week = 3 weeks At 2.4mg/week = 1.25 weeks 5mg vial: At 0.25mg/week = 20 weeks At 0.5mg/week = 10 weeks At 1mg/week = 5 weeks At 1.7mg/week = ~3 weeks At 2.4mg/week = ~2 weeks A 5mg vial can cover the entire first 4 months of a slow escalation protocol starting at 0.25mg
10.1016/s0966-842x(99)01494-8 39 SaadS
After centrifugation for 20 min (10.000 rpm, 4 C), the supernatant was stored at 80 C until further analysis
As a result, copper-based interventions that trigger cell death offer a promise for developing novel anticancer strategies
