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Roux-en-Y gastric bypass surgery (RYGB) but not sleeve gastric bypass surgery or gastric banding, increases the risk of vitamin B 12 deficiency and requires preventive post-operative treatment with either injected or high-dose oral supplementation

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Methionine is easily converted to S-adenosylmethionine (SAM), the primary methyl donor in various methylation reactions, including DNA methylation and neurotransmitter synthesis

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It is important for individuals to consult with a healthcare provider before starting vitamin B12 injections to ensure they are suitable candidates

These methods help define how AOD 9604 interacts with cellular signaling networks at the molecular level