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KPV adds three capabilities that GLOW lacks: 1

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Consequently, many AML subtypes display marked dependence on cystine uptake mediated by the system xc- (SLC7A11) antiporter, which imports extracellular cystine for subsequent reduction to cysteine and incorporation into glutathione for antioxidant defense [46,47]

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For instance, combining carnosine with carrier molecules or developing sustained-release formulations can extend its action time in vivo and increase the drug concentration in target tissues (29)

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