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AOD-9604 has superior plasma stability (longer half-life) and is the only fragment that completed Phase 2b clinical trials in obesity

It does not reverse calcification

doi: 10.1007/s11655-023-3744-7 102 ZhangNLuFLiZZhaoHPangMYeTet al

It normalized the AST, ALT, and ALP levels in obese rats

Hahn A, Zuryn S (2019) Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species

However, there are pros and cons of increasing dietary intake of GABA in long term and it is predicted that it might prevent and alleviate high blood pressure effects (Gramazio et al., 2020)
