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National concern about drug interactions with cytochrome P (CYP)-450 enzymes was heightened when fatal cardiac arrhythmias were suspected to be connected to enzymatic interactions between terfenadine and erythromycin or ketoconazole

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(1977) Effects of exposure to acrolein vapor in hamsters simultaneously treated with benzo [a] pyrene or diethylnitrosamine

doi: 10.2337/diacare.18.8.1160 28 ZieglerDLowPALitchyWJBoultonAJVinikAIFreemanRet al