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Fasting glucose levels improved across all dose groups, and insulin sensitivity markers showed meaningful improvement

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The resulting enhancement of connective tissue integrity makes it a key focus in musculoskeletal regeneration and aging-related bone metabolism research

Unlike the small molecule CB1 inhibitors currently in development, nimacimabs differentiating peripheral restriction has the potential to demonstrate the same weight loss and metabolic benefits previously seen in clinical trials by first-generation CB1 inhibitors, without the significant neuropsychiatric liabilities that continue to plague its small molecule counterparts

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