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Description
Thrombin acts on fibrinogen to create fibrin particles, which combine to produce a blood clot

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However, its associations with a pro-metastatic phenotype and therapy resistance make it an attractive target especially in tumor types characterized by highly aggressive behavior, short survival, and absence of effective treatment options

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Mutat Res 480481:23141 Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD (2008) Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
