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Incretin-based agents are also not expected to cause clinically significant cytochrome P450 (CYP)-mediated pharmacokinetic interactions, meaning the metabolism of testosterone is unlikely to be directly affected

Oral delivery is more convenient but raises real questions about how much survives digestion

3 A more extensive list of drugs associated with acneiform eruptions includes halogenated aromatic hydrocarbons, antibiotics, nystatin, corticotropin, naproxen, hydroxychloroquine, oral contraceptives, halogenated chemicals, immunosuppressants, lithium, anticonvulsants, epidermal growth factor receptor inhibitors, tumor necrosis factor alpha antagonists, and vitamins B1 and B6 ( Table 1 )

It was suggested that downregulation of hepatocellular IGF-2R/M6PR and upregulation of IGF-2 might be early events in hepatocarcinogenesis (131)

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