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MATERIALS AND METHODS Study Design This study was a single-site, double-blind study carried out at Leiden University Medical Center (LUMC) and is summarized in the Consolidated Standards of Reporting Trials (CONSORT) flow diagram (Figure 1)

The observed reduction in HbA1c confirms the expected glycemic benefit of GLP-1 agonists, consistent with previous large-scale trials [16]

also known as cobalamin, is an important water-soluble vitamin
