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Research has demonstrated that the utilization of HIF-1 inhibitors (PX-478) in LN mouse models effectively delays the recruitment of T cells to the kidneys, reverses the detrimental effects of T cells on tissue, and ameliorates kidney damage (158)

Acknowledgements The authors wish to thank Hossein Ansari, Javad Tarrahi, Dr

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Trompette A, Gollwitzer ES, Yadava K, et al

Generally, PD shows major pathology through dopaminergic neuron degeneration in the substantia nigra, causing an approximately 80% decline of dopamine levels in the striatum ( Glutamate represents the dominant excitatory neurotransmitter across central nervous system pathways