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Mitochondrial dysfunction is a common feature of neurodegenerative diseases, exacerbating ROS overproduction [67,68,87]

636 Protein arginine methyltransferase 2 (PRMT2) is involved in the regulation of -catenin through arginine methylation, which promotes proteasomal degradation of -catenin, leading to transcriptional inhibition of GPX4

Oyeleke and Owoyele 2022)

The intake of capsules containing 500 mg of curcumin powder (1500 mg per day) for 12 weeks significantly decreases glucose and DHEA levels in patients with PCOS11

Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)

However, the brain is particularly vulnerable to oxidative damage due to the high levels of unsaturated lipids, oxygen, redox metal ions, and relatively poor antioxidant systems