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Clinical application of cisplatin (CP), a widely prescribed drug in cancer chemotherapy, is sometimes associated with undesirable side effects, particularly in the gastrointestinal tract [195]

Various extraction techniquesincluding hot water, ultrasonic assisted, and microbial fermentation methodshave been developed to isolate BSPs, with extraction parameters significantly influencing its structural features

Target relevant proteins or key enzymes in the pH regulation mechanism within tumor cells to reduce the production of acidic products

PMID: 34473437

doi: 10.1016/j.biochi.2012.11.017 55

further demonstrated that temperature cycles38.5C for 12 h followed by 35.5C for 12 hourscould induce antiphase oscillations (180 shift) between IVDs and articular cartilage, while also amplifying rhythm amplitude (Goh et al., 2016)