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Based on pharmacokinetic considerations, it is proposed that an IV bolus dose of 510 mg/kg followed by a continuous infusion of 12 mg/kg/h is more likely to achieve sustained supraphysiological concentrations of Lcarnitine

Severe MCADD was defined by an ACADM genotype historically associated with clinical ascertainment, or residual MCAD activity 10%, as previously published

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In: Bendich A, Decklebaum RJ, eds

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