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The initial weeks involve adaptation to reduced caloric intake and altered hunger signaling

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10.1152/physrev.00035.2007 [DOI] [PubMed] [Google Scholar] 23.Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, et al

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Research shows that when PARP1 depletes cellular NAD+, it disrupts the NAD+/SIRT1 system, which leads to faulty DNA repair and reduced cell survival