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194,195 The activated PI3K catalyzes the conversion of membrane phospholipid Phosphatidylinositol-4,5-bisphosphate (PIP2) into Phosphatidylinositol-3,4,5-trisphosphate (PIP3)

The symptoms of low B12 are related to each of these areas

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A mild response ( 75%), moderate response (50%-75%), mild response ( 75% re-pigmentation) was achieved in 12% (eight) of the patients, 68% (44) of the patients showed moderate response, and 15% (10) had mild response (Figure 1)

Improvements in cardiometabolic markers, including blood pressure, lipid profiles, and glycaemic control, were also observed