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Although lowering Hcy using B vitamins has no beneficial effect on secondary prevention of cardiovascular disease, the role of Hcy in primary disease prevention has not been fully studied
Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE
HIF-1 can enhance cell metabolism under hypoxic conditions and contribute to the activation of VEGF to induce tumor angiogenesis
Primary oxygen free radicals are superoxide and hydroxyl radical
doi: 10.1016/j.tox.2007.11.021
