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Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels ( Figure 1 This review summarizes how changes in hepatic exposure to intra-portal insulin in health and disease states modulates the GH/IGF-I axis

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Typically, treatment will be once each week for 2-6 weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] 251.Lau W.L., Kalantar-Zadeh K., Vaziri N.D

No serious adverse events reported
