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Hence, why would I expose my patient to the risks of an unknown compound that has never been tested rigorously in humans when I can get the same results with PRP which has been tested for orthopedic applications in dozens of randomized controlled trials in humans

Long-term data beyond 12 weeks in humans does not exist from controlled trials

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ECM breakdown by proteases Cleavage of ECM components is the main process during ECM remodelling and is important for regulating ECM abundance, composition and structure, as well as for releasing biologically active molecules (such as growth factors)

Figure 17.3.5 is a summary of the pituitary hormones and their principal effects