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Description
By binding to the MT1 and MT2 receptors, melatonin can stimulate the expression and activity of enzymes such as superoxide dismutase (SODwhich reduces the superoxide radical O 2 to H 2 O 2 ), catalase (which decomposes hydrogen peroxide into water and oxygen), and glutathione peroxidase and glutathione reductase (which catalyze the GSSH/GSH reaction that is responsible for activating the antioxidant activity of glutathione, which decomposes hydrogen peroxide)

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Superior Tissue Repair and Wound Healing 1) Mechanism: - Copper ions (Cu) act as critical cofactors for repair enzymes (e.g., lysyl oxidase), enhancing collagen and elastin cross-linking to accelerate wound closure

Cardiovascular outcomes have been studied in diabetes programs, but long-term cardiovascular and renal effects need continued follow-up through registries and post-marketing safety data

The body produces its own glutathione, but levels may be depleted by poor diet, pollution, toxins, stress, ageing and infections

Am J Respir Crit Care Med 156:425430
