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Although amelioration of penile deformity was not examined in an RCT comparing shock wave therapy alone with shock wave therapy plus PDE5Is, other investigators drew the conclusion that continuous therapy of PDE5Is may be a candidate in treatment of PD based on the significant improvement of observational parameters (Palmieri et al., 2012

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This constant cardiovascular strain, combined with the brain receiving inadequate blood flow (cerebral hypoperfusion), results in severe physical and cognitive fatigue

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