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Side effect comparison: Nausea: Tirzepatide rates range from 12% to 33% depending on dose, comparable to cagrilintide Vomiting: Tirzepatide higher than cagrilintide Diarrhea: Similar rates Injection site reactions: Cagrilintide significantly higher than tirzepatide Fatigue: Tirzepatide fatigue is commonly reported, comparable to cagrilintide Some researchers are exploring cagrilintide combined with tirzepatide for potentially enhanced effects

The double-blind placebo control in this study eliminates this as an explanation for the results

doi: 10.4172/2161-069X.1000462 33

They observed links between patient-reported pain and profibrotic interleukin-10 levels and M2 remodelling macrophages, which cause the pain associated with fibrosis

Avoid use with direct acids, retinoids, and strong antioxidants

In the TME, high levels of fatty acids lead TAMs to polarize towards the M2 phenotype 128,129