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Description
The first structure of the AR LBD was solved with the AR in complex with the potent synthetic androgen R1881 (metribolone) (Figure 3A) and shows the AR in an agonist conformation with the ligand inside of the LBP formed by H3, H5, and H11 (PDB: 1E3G) (Figure 2D and 3B) 57
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Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs
Food preparation methods that utilize high heat, such as frying, grilling, and broiling, lead to the formation of more AGEs, while cooking at lower temperatures, shorter cooking times, steaming, boiling, and the use of acids like lemon juice or vinegar in cooking minimize AGE formation (Uribarri 2010)

More double-blinded randomized placebo trials and careful experimental design are needed to assess the range of beneficial effects of these strategies, which would also benefit from the metagenomics and metatranscriptomics approaches
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