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Epalrestat enhances the chemosensitivity of cancer cells to doxorubicin by inhibiting the activity of AKR1B1 and/or AKR1B10 as well as by preventing epithelial-mesenchymal transition [145]
Our data also suggested a system-wide loss of metabolic coordination across various organs in the tumor-bearing mice, which was uniquely evidenced by the downregulation of the HBP throughout the entire body
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