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cerevisiae was modified by modulating the intracellular levels of glutathione by overexpressing three genes involved in glutathione biosynthesis and metabolism: GSH1, CYS3 and GLR1 (Figure 1)

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For example, it overexpression in breast cancer activates the AKT/FOXO signaling pathway, promoting cell proliferation, invasion, and migration both in vitro and in vivo

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Altogether, these proteins may contribute to modulating the metastatic potential of cancer cells [61,62]

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J Clin Invest 2012;122:3476-3489

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A significant study in lipidomics identified a set of 26 sphingolipids and glycerophospholipids that can effectively differentiate between patients with Alzheimer's disease (AD) and cognitively normal individuals (152)

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