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doi: 10.1007/s10637-013-0047-4 137 MichelakisEDSutendraGDromparisPWebsterLHaromyANivenEet al

doi: 10.1155/2014/719050 20 PatelS

[195] obtained outer-membrane vesicles (OMVs) from attenuated Klebsiella pneumonia and prepared DOX-loaded OMVs, which were efficiently transported into A549 cells and presented substantial tumor growth inhibition with favorable tolerability and pharmacokinetic profiles

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In contrast, the hydroxyl groups in cafestol may enhance surface hydrophilicity at neutral pH 7 (water), promoting adsorption of hydrated anions and slightly increasing the negative potential [70, 71]