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Pathway enrichment analysis revealed that these genes were enriched in 170 signaling pathways, and the top 20 signaling pathways most closely related to AD were the following (Supplementary Table 2): AD-related pathways include neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, calcium signaling pathway, cAMP signaling pathway, MAPK signaling pathway, Ras signaling pathway, serotonergic synapse, pathways of neurodegeneration multiple diseases, Rap1 signaling pathway, AD and AGE-RAGE signaling pathway in diabetic complications

La L-carnitina se asocia principalmente al transporte de grasas hacia la mitocondria

The H3 receptors are acting as a feedback loop to restrict histamine and other neurotransmitter release in certain brain regions.[ref] The study also linked histaminergic neuron expression and changes in the brain to ADHD and major depressive disorder

A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology

However, the mainstream view associates DM with iron excess, which induces oxidative stress and ferroptosis (160)

Another function of Tau is revealed by its presence in the nucleus, where it has been reported to play roles in heterochromatin organization and chromatin stability by binding and interaction with heterochromatin, as well as modifying the liquidliquid phase separation (LLPS) characteristic of chromatin components (Abasi et al., 2024)