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Homocysteine can be degraded not only through the METZ but also through the transsulfuration pathway

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It is also an independent risk factor for non-communicable diseases

As was already mentioned, several studies have demonstrated that metallothionein has different functions, including the detoxification of heavy metals, antioxidant activity, neuroprotection, anticancer activity, and anti-inflammatory effects (Figure 3)

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Similar metabolic perturbations and cell necrosis were evident in cancer tissue interfered by selenite in in vivo experiments, suggesting that selenite is also a potential therapeutic direction to affect lung carcinogenesis through targeting GLS (31)