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The first enzyme involved is NADPH oxidase (NOX) that produces O 2

When SeC@PA is delivered to biofilms with high GSH levels, OH, which is more toxic than 1 O 2 (mainly produced by Ce6), is generated during irradiation through a series of cascade decomposition reactions

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NAD+ itself doesn't absorb well orally because of its molecular weight, which explains why most supplements contain precursors like nicotinamide riboside

The excessive accumulation of free radicals resulting from this process causes direct oxidative damage to the mitochondrial membrane, inducing necrosis and ultimately leading to cell death

Selected References Salehpour S, Sene AA, Saharkhiz N, Sohrabi MR, Moghimian F