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demonstrated that SIRT3 deficiency worsens NAFLD from a high-fat diet through impaired intestinal permeability linked to gut microbial dysbiosis in SIRT3 knockout mice

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its deficiency affects testicular mass with damage to sperm motility, the sperm mid piece, and the shape of the sperm (21)

These attributes significantly augment their suitability for brain-specific drug delivery applications (123)

Archives Med Sci 12:486493 Cha B, Lim JW, Kim H (2015) Jak1/Stat3 is an upstream signaling of NF-B activation in Helicobacter pylori-induced IL-8 production in gastric epithelial AGS cells