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Gastrointestinal complications are also seen, with signs of ulceration mainly affecting the stomach and less frequently the duodenum

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10.1093/toxsci/kfm148 112 MeolaJ.RosaE.SilvaJ

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HC CD19B p = 0.851, CD4T p = 0.241, CD8T p = 0.358)

Concomitantly, ROS can oxidatively activate Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) via methionine oxidation (e.g., Met281/282 oxidation), producing sustained kinase activity that phosphorylates mitochondrial Ca 2+ handling proteins such as the mitochondrial calcium uniporter (MCU) or its regulatory subunits