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MELATONIN SECRETION DEPENDING ON AGE The onset of melatonin secretion in humans during the circadian rhythm begins after the sixth week of life

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Mucosal enzyme activity of -glutamylcysteine synthetase (GCS) and -glutamyl transferase (GT) was analysed

Currently, temozolomide (TMZ) is the first-line drug for GBM treatment of which efficacy is unfortunately hindered by short circulation time and drug resistance associated to hypoxia and redox tumor microenvironment

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To synthesize current evidence on structural, cellular, metabolic, and neuro-immune mechanisms of lacrimal gland (LG) aging in humans and animal models, and to map translational strategies for age-related aqueous-deficient dry eye (ADDE)