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A deficiency in *thiamine* can lead to neurological disorders, including peripheral neuropathy, which manifests as numbness, tingling, and weakness

2) This comprehensive study performed by the research team of McCoy et al aimed to develop metabolically stable AngIV analogs with enhanced blood-brain barrier (BBB) permeability and procognitive activity, specifically focusing on a molecule named Dihexa

Second-line treatments have also been designed over the past few years, including regorafenib (antiangiogenesis) (Zhu et al., 2019)

Biorad Laboratories, Hercules, CA)

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The solution is less stable than the lyophilisate, and after the first opening of the applicator the stability window shortens