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[15] The first study recorded to have a blinded researcher was published in 1907 by W

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J Cell Biol 216:463476 Dixon DP, Cummins I, Cole DJ, Edwards R (1998) Glutathione-mediated detoxification systems in plants

Measurable improvements on nerve function testing typically require 3 to 6 months

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Although this was an open-label study, without a placebo control group, and as such has some limitations, the study results were able to demonstrate that taking ALA was linked to lower triglycerides, fewer neuropathic symptoms, and a better quality of life